Corona Virus disease 19 (Covid-19) merupakan salah satu pandemi yang telah meluas ke hampir semua negara di dunia, termasuk Indonesia. Akibatnya, berdampak ke berbagai jenis sektor tidak hanya kesehatan, namun juga sistem perbankan salah satunya bank umum syariah. Tujuan penelitian ini untuk menganalisis pengaruh CAR, NPF, FDR, Inflasi, dan BI Rate terhadap profitabilitas bank umum syariah dimasa pandemi Covid-19. Penelitian ini merupakan penelitian kuantitatif dengan data sekunder, jumlah sampel 10 bank umum syariah dengan laporan keuangan triwulan selama tahun 2020, sehingga diperoleh 40 data observasi. Penelitian ini menggunakan metode analisis regresi data panel dengan pendekatan Random Effect Model menggunakan alat analisis Eviews versi 9. Hasil penelitian ini menunjukkan bahwa secara CAR berpengaruh positif dan signifikan terhadap ROA. Selanjutnya NPF berpengaruh negatif dan signifikan terhadap ROA. Sedangkan FDR, Inflasi, dan Bi Rate tidak berpengaruh signifikan terhadap ROA. Koefisien determinan (Adjusted R2) sebesar 0.396327 atau 39% yang artinya bahwa kelima varibel independen dapat menjelaskan variabel dependen, sedangkan sisanya dipengaruhi oleh faktor lain diluar variabel penelitian. Kata Kunci: Profitabilitas, CAR, NPF, FDR, Inflasi, BI Rate.

Corona Virus disease 19 (Covid-19) is one of the pandemics that has spread to almost all countries in the world, including Indonesia. As a result, it affects not only health sectors, but also the banking system of sharia commercial banks. The purpose of this study was to analyze the influence of CAR, NPF, FDR, Inflation, and BI Rate on the profitability of sharia commercial banks during the Covid-19 pandemic. This research is a quantitative study with secondary data, the number of samples of 10 sharia commercial banks with quarterly financial statements during 2020, so that 40 observation data were obtained. This study used the data panel regression analysis method with Random Effect Model approach using Eviews version 9 analysis tool. The results of this study show that CAR has a positive and significant effect on ROA. Furthermore, NPF has a negative and significant effect on ROA. Meanwhile, FDR, Inflation, and Bi Rate have no significant effect on ROA. The coefficient of determinant (Adjusted R2) is 0.396327 or 39% which means that the five independent variables can explain dependent variables, while the rest is influenced by other factors outside the research variables. Keywords: Profitability, CAR, NPF, FDR, Inflation, BI Rate.

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